Novel macromolecular inhibitors of human immunodeficiency virus-1 protease

An intracellularly expressed defective human immunodeficiency virus type-1 (HIV-1) protease (PR) monomer could function as a dominant-negative inhibitor of the enzyme that requires dimerization for activity. Based on in silico studies, two mutant PRs harboring hydrophilic mutations, capable of formi...

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Bibliographic Details
Main Authors: Miklóssy, Gabriella, Tözsér, József, Kádas, János, Ishima, Rieko, Louis, John M., Bagossi, Péter
Format: Artigo
Language:Inglês
Published: Oxford University Press 2008
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902902/
https://ncbi.nlm.nih.gov/pubmed/18480092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/protein/gzn022
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