Novel V600E BRAF Mutations in Imatinib-Naive and Imatinib-Resistant Gastrointestinal Stromal Tumors

BRAF and NRAS are commonly mutated in cancer and represent the most frequent genetic events in malignant melanoma. More recently, a subset of melanomas was shown to overexpress KIT and harbor KIT mutations. Although most gastrointestinal stromal tumors (GISTs) exhibit activating mutations in either...

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Hlavní autoři: Agaram, Narasimhan P., Wong, Grace C., Guo, Tianhua, Maki, Robert G., Singer, Samuel, DeMatteo, Ronald P., Besmer, Peter, Antonescu, Cristina R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902874/
https://ncbi.nlm.nih.gov/pubmed/18615679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gcc.20589
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