The iron chelator deferasirox enhances liposomal amphotericin B efficacy in treating murine invasive pulmonary aspergillosis

OBJECTIVES: Increased bone marrow iron levels in patients with haematological malignancies is an independent risk factor for developing invasive pulmonary aspergillosis (IPA), suggesting an important role for iron uptake in the pathogenesis of IPA. We sought to determine the potential for combinatio...

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Autors principals: Ibrahim, Ashraf S., Gebremariam, Teclegiorgis, French, Samuel W., Edwards, John E., Spellberg, Brad
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2010
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902852/
https://ncbi.nlm.nih.gov/pubmed/19942619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkp426
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