The iron chelator deferasirox enhances liposomal amphotericin B efficacy in treating murine invasive pulmonary aspergillosis

OBJECTIVES: Increased bone marrow iron levels in patients with haematological malignancies is an independent risk factor for developing invasive pulmonary aspergillosis (IPA), suggesting an important role for iron uptake in the pathogenesis of IPA. We sought to determine the potential for combinatio...

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Main Authors: Ibrahim, Ashraf S., Gebremariam, Teclegiorgis, French, Samuel W., Edwards, John E., Spellberg, Brad
格式: Artigo
語言:Inglês
出版: Oxford University Press 2010
主題:
Original Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902852/
https://ncbi.nlm.nih.gov/pubmed/19942619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkp426
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