The iron chelator deferasirox protects mice from mucormycosis through iron starvation

Mucormycosis causes mortality in at least 50% of cases despite current first-line therapies. Clinical and animal data indicate that the presence of elevated available serum iron predisposes the host to mucormycosis. Here we demonstrate that deferasirox, an iron chelator recently approved for use in...

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Bibliographic Details
Main Authors: Ibrahim, Ashraf S., Gebermariam, Teclegiorgis, Fu, Yue, Lin,, Lin, Husseiny, Mohamed I., French, Samuel W., Schwartz, Julie, Skory, Christopher D., Edwards, John E., Spellberg, Brad J.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2007
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1957543/
https://ncbi.nlm.nih.gov/pubmed/17786247
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32338
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