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Palladium-catalyzed alkene carboamination reactions for the synthesis of substituted piperazines
A strategy for the stereoselective preparation of enantiomerically enriched cis-2,6-disubstituted piperazines from amino acid precursors is described. The target compounds are generated in 95–99% ee with good to excellent levels of diastereoselectivity (usually 14:1 to >20:1) using Pd-catalyzed c...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2902800/ https://ncbi.nlm.nih.gov/pubmed/20640043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2009.04.017 |
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