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A Concise Asymmetric Synthesis of cis-2,6-Disubstituted N-Aryl Piperazines via Pd-Catalyzed Carboamination Reactions

[Image: see text] A concise, modular, asymmetric synthesis of cis-2,6-disubstituted piperazines from readily available amino acid precursors is described. The key step in the synthesis is a Pd-catalyzed carboamination of a N(1-)aryl-N(2)-allyl-1,2-diamine with an aryl bromide. The products are obtai...

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書誌詳細
主要な著者: Nakhla, Josephine S., Wolfe, John P.
フォーマット: Artigo
言語:Inglês
出版事項: 2007
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730114/
https://ncbi.nlm.nih.gov/pubmed/17650007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ol071241f
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