INTRATHECAL INJECTION OF AN ALPHA 7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONIST ATTENUATES GP120-INDUCED MECHANICAL ALLODYNIA AND SPINAL PRO-INFLAMMATORY CYTOKINE PROFILES IN RATS

Nicotinic acetylcholine receptors (nAchR) are key receptors in the autonomic nervous system, but also are present on immune cells. The alpha seven subunit of nAchR (α7nAchR) suppresses pro-inflammation in peripheral monocytes by decreasing proinflammatory cytokine production. In spinal cord, α7nAchR...

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Autori principali: Loram, Lisa C, Harrison, Jacqueline A, Chao, Lindsey, Taylor, Frederick R, Reddy, Anireddy, Travis, Carissa L, Giffard, Rona, Al-Abed, Yousef, Tracey, Kevin, Maier, Steven F, Watkins, Linda R
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902784/
https://ncbi.nlm.nih.gov/pubmed/20353818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2010.03.008
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