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Granulin-Epithelin Precursor (GEP) Binds Directly to ADAMTS-7 and ADAMTS-12 and Inhibits Their Degradation of Cartilage Oligomeric Matrix Protein
OBJECTIVE: ADAMTS-7 and ADAMTS-12, two members of the ADAMTS (adisintegrin and metalloprotease with thrombospondin motifs) family, associate with and degrade COMP by binding to the EGF domain of COMP. Granulin-epithelin precursor (GEP) is a secreted growth factor that mediates tissue regeneration, t...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2902708/ https://ncbi.nlm.nih.gov/pubmed/20506400 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.27491 |
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