Inhibition of ADAMTS-7 and ADAMTS-12 Degradation of Cartilage Oligomeric Matrix Protein by Alpha-2-Macroglobulin

OBJECTIVE: As we previously reported, ADAMTS-7 and ADAMTS-12, two members of ADAMTS (adisintegrin and metalloprotease with thrombospondin motifs) family, degrade COMP in vitro and are significantly induced in the cartilage and synovium of arthritic patients. The purpose of this study was to determin...

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Détails bibliographiques
Auteurs principaux: Luan, Yi, Kong, Li, Howell, Damani R., Ilalov, Kiril, Fajardo, Marc, Bai, Xiao-hui, Di Cesare, Paul E., Goldring, Mary B., Abramson, Steven B., Liu, Chuan-ju
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2574789/
https://ncbi.nlm.nih.gov/pubmed/18485748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2008.03.017
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