Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors

Human immunodeficiency virus (HIV) RNase H activity is essential for the synthesis of viral DNA by HIV reverse transcriptase (HIV-RT). RNA cleavage by RNase H requires the presence of divalent metal ions, but the role of metal ions in the mechanism of RNA cleavage has not been resolved. We measured...

Whakaahuatanga katoa

Ngā taipitopito rārangi puna kōrero

I whakaputaina i:	Nucleic Acids Res
Ngā kaituhi matua:	Klumpp, Klaus, Hang, Julie Qi, Rajendran, Surendran, Yang, Yanli, Derosier, Andre, In, Philippe Wong Kai, Overton, Hilary, Parkes, Kevin E. B., Cammack, Nick, Martin, Joseph A.
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Oxford University Press 2003
Ngā marau:	Articles
Urunga tuihono:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC290251/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14627818/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg881
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!