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Two-metal ion mechanism of RNA cleavage by HIV RNase H and mechanism-based design of selective HIV RNase H inhibitors

Human immunodeficiency virus (HIV) RNase H activity is essential for the synthesis of viral DNA by HIV reverse transcriptase (HIV-RT). RNA cleavage by RNase H requires the presence of divalent metal ions, but the role of metal ions in the mechanism of RNA cleavage has not been resolved. We measured...

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Published in:Nucleic Acids Res
Main Authors: Klumpp, Klaus, Hang, Julie Qi, Rajendran, Surendran, Yang, Yanli, Derosier, Andre, In, Philippe Wong Kai, Overton, Hilary, Parkes, Kevin E. B., Cammack, Nick, Martin, Joseph A.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2003
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Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC290251/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14627818/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkg881
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