Dissolution Enhancement of a Drug Exhibiting Thermal and Acidic Decomposition Characteristics by Fusion Processing: A Comparative Study of Hot Melt Extrusion and KinetiSol® Dispersing

In this study, hot melt extrusion (HME) and KinetiSol® Dispersing (KSD) were utilized to prepare dissolution-enhanced solid dispersions of Roche Research Compound A (ROA), a BCS class II drug. Preformulation characterization studies showed that ROA was chemically unstable at elevated temperatures an...

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Detalhes bibliográficos
Main Authors: Hughey, Justin R., DiNunzio, James C., Bennett, Ryan C., Brough, Chris, Miller, Dave A., Ma, Hua, Williams, Robert O., McGinity, James W.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902338/
https://ncbi.nlm.nih.gov/pubmed/20443089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12249-010-9431-y
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