Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways

Glial fibrillary acidic protein (GFAP) is the principle intermediate filament (IF) protein in astrocytes. Mutations in the GFAP gene lead to Alexander disease (AxD), a rare, fatal neurological disorder characterized by the presence of abnormal astrocytes that contain GFAP protein aggregates, termed...

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Bibliographische Detailangaben
Hauptverfasser: Tang, Guomei, Yue, Zhenyu, Talloczy, Zsolt, Hagemann, Tracy, Cho, Woosung, Messing, Albee, Sulzer, David L., Goldman, James E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2008
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902290/
https://ncbi.nlm.nih.gov/pubmed/18276609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddn042
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