Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators

To identify the genetic basis of circulating concentrations of monocyte chemoattractant protein-1 (MCP-1), we conducted genome-wide association analyses for MCP-1 in 3 independent cohorts (n = 9598). The strongest association was for serum MCP-1 with a nonsynonymous polymorphism, rs12075 (Asp42Gly)...

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Opis bibliograficzny
Główni autorzy: Schnabel, Renate B., Baumert, Jens, Barbalic, Maja, Dupuis, Josée, Ellinor, Patrick T., Durda, Peter, Dehghan, Abbas, Bis, Joshua C., Illig, Thomas, Morrison, Alanna C., Jenny, Nancy S., Keaney, John F., Gieger, Christian, Tilley, Cathy, Yamamoto, Jennifer F., Khuseyinova, Natalie, Heiss, Gerardo, Doyle, Margaret, Blankenberg, Stefan, Herder, Christian, Walston, Jeremy D., Zhu, Yanyan, Vasan, Ramachandran S., Klopp, Norman, Boerwinkle, Eric, Larson, Martin G., Psaty, Bruce M., Peters, Annette, Ballantyne, Christie M., Witteman, Jacqueline C. M., Hoogeveen, Ron C., Benjamin, Emelia J., Koenig, Wolfgang, Tracy, Russell P.
Format: Artigo
Język:Inglês
Wydane: American Society of Hematology 2010
Hasła przedmiotowe:
Plenary Paper
Dostęp online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902130/
https://ncbi.nlm.nih.gov/pubmed/20040767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-221382
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