Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators

To identify the genetic basis of circulating concentrations of monocyte chemoattractant protein-1 (MCP-1), we conducted genome-wide association analyses for MCP-1 in 3 independent cohorts (n = 9598). The strongest association was for serum MCP-1 with a nonsynonymous polymorphism, rs12075 (Asp42Gly)...

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Main Authors: Schnabel, Renate B., Baumert, Jens, Barbalic, Maja, Dupuis, Josée, Ellinor, Patrick T., Durda, Peter, Dehghan, Abbas, Bis, Joshua C., Illig, Thomas, Morrison, Alanna C., Jenny, Nancy S., Keaney, John F., Gieger, Christian, Tilley, Cathy, Yamamoto, Jennifer F., Khuseyinova, Natalie, Heiss, Gerardo, Doyle, Margaret, Blankenberg, Stefan, Herder, Christian, Walston, Jeremy D., Zhu, Yanyan, Vasan, Ramachandran S., Klopp, Norman, Boerwinkle, Eric, Larson, Martin G., Psaty, Bruce M., Peters, Annette, Ballantyne, Christie M., Witteman, Jacqueline C. M., Hoogeveen, Ron C., Benjamin, Emelia J., Koenig, Wolfgang, Tracy, Russell P.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2010
Teme:
Plenary Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902130/
https://ncbi.nlm.nih.gov/pubmed/20040767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-221382
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