Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators

To identify the genetic basis of circulating concentrations of monocyte chemoattractant protein-1 (MCP-1), we conducted genome-wide association analyses for MCP-1 in 3 independent cohorts (n = 9598). The strongest association was for serum MCP-1 with a nonsynonymous polymorphism, rs12075 (Asp42Gly)...

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Detalhes bibliográficos
Main Authors: Schnabel, Renate B., Baumert, Jens, Barbalic, Maja, Dupuis, Josée, Ellinor, Patrick T., Durda, Peter, Dehghan, Abbas, Bis, Joshua C., Illig, Thomas, Morrison, Alanna C., Jenny, Nancy S., Keaney, John F., Gieger, Christian, Tilley, Cathy, Yamamoto, Jennifer F., Khuseyinova, Natalie, Heiss, Gerardo, Doyle, Margaret, Blankenberg, Stefan, Herder, Christian, Walston, Jeremy D., Zhu, Yanyan, Vasan, Ramachandran S., Klopp, Norman, Boerwinkle, Eric, Larson, Martin G., Psaty, Bruce M., Peters, Annette, Ballantyne, Christie M., Witteman, Jacqueline C. M., Hoogeveen, Ron C., Benjamin, Emelia J., Koenig, Wolfgang, Tracy, Russell P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2010
Assuntos:
Plenary Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2902130/
https://ncbi.nlm.nih.gov/pubmed/20040767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-221382
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