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Na(V)1.1 channels and epilepsy

Voltage-gated sodium channels initiate action potentials in brain neurons, and sodium channel blockers are used in therapy of epilepsy. Mutations in sodium channels are responsible for genetic epilepsy syndromes with a wide range of severity, and the Na(V)1.1 channel encoded by the SCN1A gene is the...

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Detalhes bibliográficos
Main Authors: Catterall, William A, Kalume, Franck, Oakley, John C
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901973/
https://ncbi.nlm.nih.gov/pubmed/20194124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.187484
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