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Na(V)1.1 channels and epilepsy

Voltage-gated sodium channels initiate action potentials in brain neurons, and sodium channel blockers are used in therapy of epilepsy. Mutations in sodium channels are responsible for genetic epilepsy syndromes with a wide range of severity, and the Na(V)1.1 channel encoded by the SCN1A gene is the...

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Autors principals: Catterall, William A, Kalume, Franck, Oakley, John C
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2010
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901973/
https://ncbi.nlm.nih.gov/pubmed/20194124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.187484
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