Functional inhibition related to structure of a highly potent insulin-specific CD8 T cell clone using altered peptide ligands

Insulin-reactive CD8 T cells are amongst the earliest islet-infiltrating CD8 T cells in NOD mice. Cloned insulin B15–23-reactive cells (designated G9C8), restricted by H-2K(d), are highly diabetogenic. We used altered peptide ligands (APL) substituted at TCR contact sites, positions (p)6 and 8, to i...

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Detalhes bibliográficos
Main Authors: Petrich de Marquesini, Liliana G, Moustakas, Antonis K, Thomas, Ian J, Wen, Li, Papadopoulos, George K, Wong, F Susan
Formato: Artigo
Idioma:Inglês
Publicado em: WILEY-VCH Verlag 2008
Assuntos:
Molecular immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901522/
https://ncbi.nlm.nih.gov/pubmed/18157812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200737762
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