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Melanocytes are deficient in repair of oxidative DNA damage and UV-induced photoproducts
Melanomas occur mainly in sunlight-exposed skin. Xeroderma pigmentosum (XP) patients have 1,000-fold higher incidence of melanoma, suggesting that sunlight-induced “bulky” photoproducts are responsible for melanomagenesis. Sunlight induces a high level of reactive oxygen species in melanocytes (MCs)...
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| Hlavní autoři: | , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2901481/ https://ncbi.nlm.nih.gov/pubmed/20566850 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1005244107 |
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