DNA-PKcs deficiency leads to persistence of oxidatively-induced clustered DNA lesions in human tumor cells

DNA-dependent protein kinase (DNA-PK) is a key non-homologous end joining (NHEJ) nuclear serine/threonine protein kinase involved in various DNA metabolic and damage signaling pathways contributing to the maintenance of genomic stability and prevention of cancer. In order to examine the role of DNA-...

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Autori principali: Peddi, Prakash, Loftin, Charles W., Dickey, Jennifer S., Hair, Jessica M., Burns, Kara J., Aziz, Khaled, Francisco, Dave C., Panayiotidis, Mihalis I., Sedelnikova, Olga A., Bonner, William M., Winters, Thomas A., Georgakilas, Alexandros G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901171/
https://ncbi.nlm.nih.gov/pubmed/20193758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.02.033
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