DNA-PKcs deficiency leads to persistence of oxidatively-induced clustered DNA lesions in human tumor cells

DNA-dependent protein kinase (DNA-PK) is a key non-homologous end joining (NHEJ) nuclear serine/threonine protein kinase involved in various DNA metabolic and damage signaling pathways contributing to the maintenance of genomic stability and prevention of cancer. In order to examine the role of DNA-...

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Bibliographic Details
Main Authors: Peddi, Prakash, Loftin, Charles W., Dickey, Jennifer S., Hair, Jessica M., Burns, Kara J., Aziz, Khaled, Francisco, Dave C., Panayiotidis, Mihalis I., Sedelnikova, Olga A., Bonner, William M., Winters, Thomas A., Georgakilas, Alexandros G.
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901171/
https://ncbi.nlm.nih.gov/pubmed/20193758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2010.02.033
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