Expansion of immunoglobulin-secreting cells and defects in B cell tolerance in Rag-dependent immunodeficiency

The contribution of B cells to the pathology of Omenn syndrome and leaky severe combined immunodeficiency (SCID) has not been previously investigated. We have studied a mut/mut mouse model of leaky SCID with a homozygous Rag1 S723C mutation that impairs, but does not abrogate, V(D)J recombination ac...

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Hoofdauteurs: Walter, Jolan E., Rucci, Francesca, Patrizi, Laura, Recher, Mike, Regenass, Stephan, Paganini, Tiziana, Keszei, Marton, Pessach, Itai, Lang, Philipp A., Poliani, Pietro Luigi, Giliani, Silvia, Al-Herz, Waleed, Cowan, Morton J., Puck, Jennifer M., Bleesing, Jack, Niehues, Tim, Schuetz, Catharina, Malech, Harry, DeRavin, Suk See, Facchetti, Fabio, Gennery, Andrew R., Andersson, Emma, Kamani, Naynesh R., Sekiguchi, JoAnn, Alenezi, Hamid M., Chinen, Javier, Dbaibo, Ghassan, ElGhazali, Gehad, Fontana, Adriano, Pasic, Srdjan, Detre, Cynthia, Terhorst, Cox, Alt, Frederick W., Notarangelo, Luigi D.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The Rockefeller University Press 2010
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2901061/
https://ncbi.nlm.nih.gov/pubmed/20547827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091927
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