Polysaccharide mimicry of the epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses to self oligomannose glycans

Immunologically, “self” carbohydrates protect the HIV-1 surface glycoprotein, gp120, from antibody recognition. However, one broadly neutralizing antibody, 2G12, neutralizes primary viral isolates by direct recognition of Manα1→2Man motifs formed by the host-derived oligomannose glycans of the viral...

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Detalhes bibliográficos
Main Authors: Dunlop, D Cameron, Bonomelli, Camille, Mansab, Fatma, Vasiljevic, Snezana, Doores, Katie J, Wormald, Mark R, Palma, Angelina S, Feizi, Ten, Harvey, David J, Dwek, Raymond A, Crispin, Max, Scanlan, Christopher N
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900896/
https://ncbi.nlm.nih.gov/pubmed/20181792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cwq020
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