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Polysaccharide mimicry of the epitope of the broadly neutralizing anti-HIV antibody, 2G12, induces enhanced antibody responses to self oligomannose glycans
Immunologically, “self” carbohydrates protect the HIV-1 surface glycoprotein, gp120, from antibody recognition. However, one broadly neutralizing antibody, 2G12, neutralizes primary viral isolates by direct recognition of Manα1→2Man motifs formed by the host-derived oligomannose glycans of the viral...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2900896/ https://ncbi.nlm.nih.gov/pubmed/20181792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/glycob/cwq020 |
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