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Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells
Mitochondrial genomes with deleterious mutations can replicate in cells along with wild-type genomes in a state of heteroplasmy, and are a cause of severe inherited syndromes, such as mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke (MELAS), neuropathy, ataxia, retinitis pigmentos...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2900690/ https://ncbi.nlm.nih.gov/pubmed/20547844 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914569107 |
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