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The UGT1A1*28 Polymorphism Correlates with Erlotinib's Effect on SN-38 Glucuronidation

The combination of irinotecan and erlotinib has been evaluated in clinical trials, although toxicity has been significant. We aimed to investigate the effect of erlotinib on SN-38 glucuronidation, and the association between UGT1A polymorphisms and SN-38 glucuronidation activity in the presence of e...

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Autori principali: Liu, Yong, Ramírez, Jacqueline, House, Larry, Ratain, Mark J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900545/
https://ncbi.nlm.nih.gov/pubmed/20580994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2010.04.022
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