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The UGT1A1*28 Polymorphism Correlates with Erlotinib's Effect on SN-38 Glucuronidation
The combination of irinotecan and erlotinib has been evaluated in clinical trials, although toxicity has been significant. We aimed to investigate the effect of erlotinib on SN-38 glucuronidation, and the association between UGT1A polymorphisms and SN-38 glucuronidation activity in the presence of e...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2900545/ https://ncbi.nlm.nih.gov/pubmed/20580994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejca.2010.04.022 |
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