Integration Preferences of Wildtype AAV-2 for Consensus Rep-Binding Sites at Numerous Loci in the Human Genome

Adeno-associated virus type 2 (AAV) is known to establish latency by preferential integration in human chromosome 19q13.42. The AAV non-structural protein Rep appears to target a site called AAVS1 by simultaneously binding to Rep-binding sites (RBS) present on the AAV genome and within AAVS1. In the...

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Autors principals: Hüser, Daniela, Gogol-Döring, Andreas, Lutter, Timo, Weger, Stefan, Winter, Kerstin, Hammer, Eva-Maria, Cathomen, Toni, Reinert, Knut, Heilbronn, Regine
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2010
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900306/
https://ncbi.nlm.nih.gov/pubmed/20628575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000985
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