Differential adeno-associated virus mediated gene transfer to sensory neurons following intrathecal delivery by direct lumbar puncture

BACKGROUND: Neuronal transduction by adeno-associated viral (AAV) vectors has been demonstrated in cortex, brainstem, cerebellum, and sensory ganglia. Intrathecal delivery of AAV serotypes that transduce neurons in dorsal root ganglia (DRG) and spinal cord offers substantial opportunities to 1) furt...

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Detalhes bibliográficos
Main Authors: Vulchanova, Lucy, Schuster, Daniel J, Belur, Lalitha R, Riedl, Maureen S, Podetz-Pedersen, Kelly M, Kitto, Kelley F, Wilcox, George L, McIvor, R Scott, Fairbanks, Carolyn A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2900238/
https://ncbi.nlm.nih.gov/pubmed/20509925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-6-31
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