Methotrexate released in vitro from bone cement inhibits human stem cell proliferation in S/G2 phase

Methotrexate (MTX) released from bone cement showed a useful local effect in animal models of bone tumours. However, local toxic reactions such as impaired wound healing were observed in areas surrounding the MTX-loaded implant. Therefore, we hypothesised that MTX released from bone cement would hav...

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Bibliografiske detaljer
Main Authors: Prochazka, Egon, Soukup, Tomas, Hroch, Milos, Fuksa, Leos, Brcakova, Eva, Cermanova, Jolana, Kolouchova, Gabriela, Urban, Karel, Mokry, Jaroslav, Micuda, Stanislav
Format: Artigo
Sprog:Inglês
Udgivet: Springer-Verlag 2009
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Original Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2899262/
https://ncbi.nlm.nih.gov/pubmed/19205701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00264-008-0717-6
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