The methylated N-terminal tail of RCC1 is required for stabilisation of its interaction with chromatin by Ran in live cells

BACKGROUND: Regulator of chromosome condensation 1 (RCC1) is the guanine nucleotide exchange factor for Ran GTPase. Localised generation of Ran-GTP by RCC1 on chromatin is critical for nucleocytoplasmic transport, mitotic spindle assembly and nuclear envelope formation. Both the N-terminal tail of R...

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Main Authors: Hitakomate, Ekarat, Hood, Fiona E, Sanderson, Helen S, Clarke, Paul R
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898669/
https://ncbi.nlm.nih.gov/pubmed/20565941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2121-11-43
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