E-selectin ligand–1 regulates growth plate homeostasis in mice by inhibiting the intracellular processing and secretion of mature TGF-β

The majority of human skeletal dysplasias are caused by dysregulation of growth plate homeostasis. As TGF-β signaling is a critical determinant of growth plate homeostasis, skeletal dysplasias are often associated with dysregulation of this pathway. The context-dependent action of TFG-β signaling is...

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Detalhes bibliográficos
Main Authors: Yang, Tao, Mendoza-Londono, Roberto, Lu, Huifang, Tao, Jianning, Li, Kaiyi, Keller, Bettina, Jiang, Ming Ming, Shah, Rina, Chen, Yuqing, Bertin, Terry K., Engin, Feyza, Dabovic, Branka, Rifkin, Daniel B., Hicks, John, Jamrich, Milan, Beaudet, Arthur L., Lee, Brendan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898604/
https://ncbi.nlm.nih.gov/pubmed/20530870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI42150
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