Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression of Sox9

Notch signaling plays a critical role during development by directing the binary cell fate decision between progenitors and differentiated cells. Previous studies have shown sustained Notch activation in cartilage leads to chondrodysplasia. Genetic evidence indicates that Notch regulates limb bud me...

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Bibliografiske detaljer
Main Authors: Chen, Shan, Tao, Jianning, Bae, Yangjin, Jiang, Ming-Ming, Bertin, Terry, Chen, Yuqing, Yang, Tao, Lee, Brendan
Format: Artigo
Sprog:Inglês
Udgivet: Wiley Subscription Services, Inc., A Wiley Company 2013
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3548081/
https://ncbi.nlm.nih.gov/pubmed/22991339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1770
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