Hyperactivation of phosphatidylinositol-3 kinase promotes escape from hormone dependence in estrogen receptor–positive human breast cancer

Many breast cancers exhibit a degree of dependence on estrogen for tumor growth. Although several therapies have been developed to treat individuals with estrogen-dependent breast cancers, some tumors show de novo or acquired resistance, rendering them particularly elusive to current therapeutic str...

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Detalhes bibliográficos
Main Authors: Miller, Todd W., Hennessy, Bryan T., González-Angulo, Ana M., Fox, Emily M., Mills, Gordon B., Chen, Heidi, Higham, Catherine, García-Echeverría, Carlos, Shyr, Yu, Arteaga, Carlos L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898598/
https://ncbi.nlm.nih.gov/pubmed/20530877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI41680
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