A kinome-wide screen identifies the Insulin/IGF-1 receptor pathway as a mechanism of escape from hormone dependence in breast cancer

Estrogen receptor α (ER)-positive breast cancers adapt to hormone deprivation and become resistant to antiestrogens. In this study, we sought to identify kinases essential for growth of ER+ breast cancer cells resistant to long term estrogen deprivation (LTED). A kinome-wide siRNA screen showed that...

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Detalhes bibliográficos
Main Authors: Fox, Emily M., Miller, Todd W., Balko, Justin M., Kuba, Maria G., Sánchez, Violeta, Smith, R. Adam, Liu, Shuying, González-Angulo, Ana María, Mills, Gordon B., Ye, Fei, Shyr, Yu, Manning, H. Charles, Buck, Elizabeth, Arteaga, Carlos L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3206206/
https://ncbi.nlm.nih.gov/pubmed/21908557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-1295
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