Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates

HSC transplantation using genetically modified autologous cells is a promising therapeutic strategy for various genetic diseases, cancer, and HIV. However, for many of these conditions, the current efficiency of gene transfer to HSCs is not sufficient for clinical use. The ability to increase the pe...

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Bibliografiske detaljer
Main Authors: Beard, Brian C., Trobridge, Grant D., Ironside, Christina, McCune, Jeannine S., Adair, Jennifer E., Kiem, Hans-Peter
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898586/
https://ncbi.nlm.nih.gov/pubmed/20551514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40767
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