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Efficient and stable MGMT-mediated selection of long-term repopulating stem cells in nonhuman primates
HSC transplantation using genetically modified autologous cells is a promising therapeutic strategy for various genetic diseases, cancer, and HIV. However, for many of these conditions, the current efficiency of gene transfer to HSCs is not sufficient for clinical use. The ability to increase the pe...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2898586/ https://ncbi.nlm.nih.gov/pubmed/20551514 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI40767 |
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