Crystal Structure of the Entire Ectodomain of gp130: INSIGHTS INTO THE MOLECULAR ASSEMBLY OF THE TALL CYTOKINE RECEPTOR COMPLEXES

gp130 is the shared signal-transducing receptor subunit for the large and important family of interleukin 6-like cytokines. Previous x-ray structures of ligand-receptor complexes of this family lack the three membrane-proximal domains that are essential for signal transduction. Here we report the cr...

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Auteurs principaux: Xu, Yibin, Kershaw, Nadia J., Luo, Cindy S., Soo, Priscilla, Pocock, Michael J., Czabotar, Peter E., Hilton, Douglas J., Nicola, Nicos A., Garrett, Thomas P. J., Zhang, Jian-Guo
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2010
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Reports
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898449/
https://ncbi.nlm.nih.gov/pubmed/20489211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.C110.129502
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