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An Autoregulatory Loop between Nrf2 and Cul3-Rbx1 Controls Their Cellular Abundance
The INrf2 (Keap1)/Cul3-Rbx1 complex constantly degrades Nrf2 under normal conditions. When a cell encounters oxidative or electrophilic stress, Nrf2 dissociates from the INrf2/Cul3-Rbx1 complex and translocates into the nucleus. In the nucleus, Nrf2 activates a myriad of antioxidant and defensive ge...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2898441/ https://ncbi.nlm.nih.gov/pubmed/20452971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.121863 |
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