Knock-in Mutation Reveals an Essential Role for Focal Adhesion Kinase Activity in Blood Vessel Morphogenesis and Cell Motility-Polarity but Not Cell Proliferation

Focal adhesion kinase (FAK) associates with both integrins and growth factor receptors in the control of cell motility and survival. Loss of FAK during mouse development results in lethality at embryonic day 8.5 (E8.5) and a block in cell proliferation. Because FAK serves as both a scaffold and sign...

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Bibliographic Details
Main Authors: Lim, Ssang-Taek, Chen, Xiao Lei, Tomar, Alok, Miller, Nichol L. G., Yoo, Jiyeon, Schlaepfer, David D.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898428/
https://ncbi.nlm.nih.gov/pubmed/20442405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.129999
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