The Selenium-independent Inherent Pro-oxidant NADPH Oxidase Activity of Mammalian Thioredoxin Reductase and Its Selenium-dependent Direct Peroxidase Activities

Mammalian thioredoxin reductase (TrxR) is an NADPH-dependent homodimer with three redox-active centers per subunit: a FAD, an N-terminal domain dithiol (Cys(59)/Cys(64)), and a C-terminal cysteine/selenocysteine motif (Cys(497)/Sec(498)). TrxR has multiple roles in antioxidant defense. Opposing thes...

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Hlavní autoři: Cheng, Qing, Antholine, William E., Myers, Judith M., Kalyanaraman, Balaraman, Arnér, Elias S. J., Myers, Charles R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898413/
https://ncbi.nlm.nih.gov/pubmed/20457604
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.117259
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