Protein Phosphatase 2A Acts as a Mitogen-activated Protein Kinase Kinase Kinase 3 (MEKK3) Phosphatase to Inhibit Lysophosphatidic Acid-induced IκB Kinase β/Nuclear Factor-κB Activation

MEKK3 is a central intermediate signaling component in lysophosphatidic acid (LPA)-induced activation of the nuclear factor-κB (NF-κB). However, the precise mechanism for the termination of MEKK3 kinase activity is not fully understood. Using a functional genomic approach, we have identified a prote...

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Bibliographic Details
Main Authors: Sun, Wenjing, Wang, Hao, Zhao, Xiumei, Yu, Yang, Fan, Yihui, Wang, Xishan, Lu, Xiongbin, Zhang, Guiyin, Fu, Songbin, Yang, Jianhua
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898379/
https://ncbi.nlm.nih.gov/pubmed/20448038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.104224
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