Type IIB Procollagen NH(2)-propeptide Induces Death of Tumor Cells via Interaction with Integrins α(V)β(3) and α(V)β(5)

Cartilage is resistant to tumor invasion. In the present study, we found that the NH(2)-propeptide of the cartilage-characteristic collagen, type IIB, PIIBNP, is capable of killing tumor cells. The NH(2)-propeptide is liberated into the extracellular matrix prior to deposition of the collagen fibril...

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Bibliographic Details
Main Authors: Wang, Zhepeng, Bryan, Jennifer, Franz, Carl, Havlioglu, Necat, Sandell, Linda J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898354/
https://ncbi.nlm.nih.gov/pubmed/20439458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.118521
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