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Repression of Retrotransposal Elements in Mouse Embryonic Stem Cells Is Primarily Mediated by a DNA Methylation-independent Mechanism

In defense of deleterious retrotransposition of intracisternal A particle (IAP) elements, IAP loci are heavily methylated and silenced in mouse somatic cells. To determine whether IAP is also repressed in pluripotent stem cells by DNA methylation, we examined IAP expression in demethylated mouse emb...

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Bibliografski detalji
Glavni autori: Hutnick, Leah K., Huang, Xinhua, Loo, Tao-Chuan, Ma, Zhicheng, Fan, Guoping
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898347/
https://ncbi.nlm.nih.gov/pubmed/20404320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.125674
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