Diadenosine Homodinucleotide Products of ADP-ribosyl Cyclases Behave as Modulators of the Purinergic Receptor P2X7

ADP-ribosyl cyclases from both vertebrates and invertebrates were previously shown to produce two isomers of P1,P2 diadenosine 5′,5′"-P1, P2-diphosphate, P18 and P24, from cyclic ADP-ribose (cADPR) and adenine. P18 and P24 are characterized by an unusual N-glycosidic linkage in one of the adeny...

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Hauptverfasser: Bruzzone, Santina, Basile, Giovanna, Chothi, Madhu Parakkottil, Nobbio, Lucilla, Usai, Cesare, Jacchetti, Emanuela, Schenone, Angelo, Guse, Andreas H., Di Virgilio, Francesco, De Flora, Antonio, Zocchi, Elena
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2898341/
https://ncbi.nlm.nih.gov/pubmed/20439466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.097964
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