Adenylic Dinucleotides Produced by CD38 Are Negative Endogenous Modulators of Platelet Aggregation

Diadenosine 5′,5‴-P1,P2-diphosphate (Ap2A) is one of the adenylic dinucleotides stored in platelet granules. Along with proaggregant ADP, it is released upon platelet activation and is known to stimulate myocyte proliferation. We have previously demonstrated synthesis of Ap2A and of two isomers ther...

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Detalhes bibliográficos
Main Authors: Magnone, Mirko, Basile, Giovanna, Bruzzese, Debora, Guida, Lucrezia, Signorello, Maria Grazia, Chothi, Madhu Parakkottil, Bruzzone, Santina, Millo, Enrico, Qi, Ai-Dong, Nicholas, Robert A., Kassack, Matthias U., Leoncini, Giuliana, Zocchi, Elena
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3259817/
https://ncbi.nlm.nih.gov/pubmed/18606819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M710568200
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