P2X7-mediated Increased Intracellular Calcium Causes Functional Derangement in Schwann Cells from Rats with CMT1A Neuropathy

Charcot-Marie-Tooth (CMT) is the most frequent inherited neuromuscular disorder, affecting 1 person in 2500. CMT1A, the most common form of CMT, is usually caused by a duplication of chromosome 17p11.2, containing the PMP22 (peripheral myelin protein-22) gene; overexpression of PMP22 in Schwann cell...

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Dettagli Bibliografici
Autori principali: Nobbio, Lucilla, Sturla, Laura, Fiorese, Fulvia, Usai, Cesare, Basile, Giovanna, Moreschi, Iliana, Benvenuto, Federica, Zocchi, Elena, De Flora, Antonio, Schenone, Angelo, Bruzzone, Santina
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
Mechanisms of Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755720/
https://ncbi.nlm.nih.gov/pubmed/19546221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.027128
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