Use of Isoform-Specific UGT Metabolism to Determine and Describe Rates and Profiles of Glucuronidation of Wogonin and Oroxylin A by Human Liver and Intestinal Microsomes

PURPOSES: Glucuronidation via UDP-glucuronosyltransferases (or UGTs) is a major metabolic pathway. The purposes of this study are to determine the UGT-isoform specific metabolic fingerprint (or GSMF) of wogonin and oroxylin A, and to use isoform-specific metabolism rates and kinetics to determine an...

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Hlavní autoři: Zhou, Qiong, Zheng, Zhijie, Xia, Bijun, Tang, Lan, Lv, Chang, Liu, Wei, Liu, Zhongqiu, Hu, Ming
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897949/
https://ncbi.nlm.nih.gov/pubmed/20411407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-010-0148-0
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