Cyclooxygenase-1 mediates prostaglandin E(2) elevation and contextual memory impairment in a model of sustained hippocampal interleukin-1β expression

Interleukin(IL)-1β is a proinflammatory cytokine implicated in several neurodegenerative disorders. Downstream actions of IL-1β include production of prostaglandin(PG)E(2) by increasing expression of cyclooxygenase (COX) enzymes and prostaglandin E synthase (PGES) isoforms. We recently developed a t...

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Autores principales: Matousek, Sarah B, Hein, Amy M., Shaftel, Solomon S., Olschowka, John A., Kyrkanides, Stephanos, O’Banion, M. Kerry
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2897946/
https://ncbi.nlm.nih.gov/pubmed/20412387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2010.06759.x
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